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Sk053, An Inhibitor Of Enzymes Involved In Allosteric Disulfide.

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Our Studies Revealed That Sk053 Is Not A Targetspecific, But Mechanismselective Inhibitor Of Allosteric Disulfide Bonds Formation That Also Blocks The Enzymatic Activity Of Pdi.

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The Present Invention Relates To A Prooxidant Synergistic Combination To Treat Bcell Malignancies, Such As B Cell Lymphomas, Which Comprises A Thioredoxin Reductase Inhibitor, Selected From A Group Comprising Auranofin And Sk053, And L Or Dascorbate.

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