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| Note that dial does not come in original packaging but with our inhouse packaging. | It is shown that sk053, a thioredoxin inhibitor, induces differentiation and cell death of acute myeloid leukemia cells, and provides a proofofconcept that protein disulfide isomerase inhibition has potential as a therapeutic strategy for the treatment of acutemyeloids leukemia and for the. | Studies toward novel peptidomimetic inhibitors of thioredoxin–. |
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| Mflsk053cz image for reference only. | Its biotinylated form sk231 precipitated pdi from human aml nb4 cells, and mass spectrometry analysis revealed that sk053 covalently binds to pdi. | Our ongoing studies revealed that sk053 is not a targetspecific, but mechanismselective inhibitor of enzymes involved in allosteric disulfide bonds formation such as protein disulfide isomerase pdi. |
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